MITI minimum information guidelines for highly multiplexed tissue images.

  title={MITI minimum information guidelines for highly multiplexed tissue images.},
  author={Denis Schapiro and Clarence Yapp and Artem Sokolov and Sheila M. Reynolds and Yu-An Chen and Damir Sudar and Yubin Xie and Jeremy L. Muhlich and Raquel Arias-Camison and Sarah Arena and Adam J Taylor and Milen Nikolov and Madison Tyler and Jia-Ren Lin and Erik A. Burlingame and Young Hwan Chang and Samouil L. Farhi and V{\'e}steinn Thorsson and Nithya Venkatamohan and Julia L. Drewes and Dana Pe’er and David A. Gutman and Markus D. Herrmann and Nils Gehlenborg and Peter Bankhead and Joseph T. Roland and John M. Herndon and Michael Paul Snyder and Michael Angelo and Garry P. Nolan and Jason R. Swedlow and Nikolaus D. Schultz and Daniel T Merrick and Sarah A Mazzili and Ethan G. Cerami and Scott J. Rodig and Sandro Santagata and Peter K. Sorger},
  journal={Nature methods},
  volume={19 3},
The imminent release of tissue atlases combining multichannel microscopy with single-cell sequencing and other omics data from normal and diseased specimens creates an urgent need for data and metadata standards to guide data deposition, curation and release. We describe a Minimum Information about Highly Multiplexed Tissue Imaging (MITI) standard that applies best practices developed for genomics and for other microscopy data to highly multiplexed tissue images and traditional histology. 

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