MIR34A regulates autophagy and apoptosis by targeting HMGB1 in the retinoblastoma cell.

@article{Liu2014MIR34ARA,
  title={MIR34A regulates autophagy and apoptosis by targeting HMGB1 in the retinoblastoma cell.},
  author={Ke Liu and Jun Huang and Min Xie and Yan Yu and Shan Zhu and Rui Kang and Lizhi Cao and Daolin Tang and Xuanchu Duan},
  journal={Autophagy},
  year={2014},
  volume={10 3},
  pages={442-52}
}
MIR34A (microRNA 34a) is a tumor suppressor gene, but how it regulates chemotherapy response and resistance is not completely understood. Here, we show that the microRNA MIR34A-dependent high mobility group box 1 (HMGB1) downregulation inhibits autophagy and enhances chemotherapy-induced apoptosis in the retinoblastoma cell. HMGB1 is a multifaceted protein with a key role in autophagy, a self-degradative, homeostatic process with a context-specific role in cancer. MIR34A inhibits HMGB1… CONTINUE READING
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