MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells.

@article{Oba2005MIP1alphaUB,
  title={MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells.},
  author={Yasuo Oba and Jun Won Lee and Lori A Ehrlich and Ho Yeon Chung and Diane F. Jelinek and Natalie S. Callander and Richard Horuk and Sun Jin Choi and Garson David Roodman},
  journal={Experimental hematology},
  year={2005},
  volume={33 3},
  pages={272-8}
}
OBJECTIVES Macrophage inflammatory protein-1alpha (MIP-1alpha), an osteoclast (OCL) stimulatory factor produced by primary multiple myeloma (MM) cells, increases bone destruction and tumor burden in murine models of MM. Several chemokine receptors (CCR1, CCR5, and CCR9) mediate the effects of MIP-1alpha. In this study, we determined which of these mediates… CONTINUE READING