MIP-1alpha expression in tissues from patients with hemophagocytic syndrome.

  title={MIP-1alpha expression in tissues from patients with hemophagocytic syndrome.},
  author={Julie Teruya-Feldstein and Joyce Setsuda and Xiao-jian Yao and Douglas William Kingma and Stephen E. Straus and Giovanna Tosato and Elaine S. Jaffe},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={79 12},
Hemophagocytic syndrome (HPS) is a clinicopathologic syndrome that can be precipitated by a variety of causes and is characterized by a systemic activation of macrophages, which are induced to undergo phagocytosis. Chemokines play an important role in the inflammatory cell recruitment into tissues. We examined the expression of chemokines and cytokines in tissues exhibiting histologic evidence of HPS in a variety of settings: peripheral T-cell lymphoma, three patients; nasal T/NK cell lymphoma… CONTINUE READING