MIP-1 a as a Critical Macrophage Chemoattractant in Murine Wound Repair

@inproceedings{DiPietro1998MIP1AA,
  title={MIP-1 a as a Critical Macrophage Chemoattractant in Murine Wound Repair},
  author={Luisa A DiPietro and Marie D. Burdick and Quentin E H Low and Steven L. Kunkel and Robert M. Strieter},
  year={1998}
}
At sites of injury, macrophages secrete growth factors and proteins that promote tissue repair. While this central role of the macrophage has been well studied, the specific stimuli that recruit macrophages into sites of injury are not well understood. This study examines the role of macrophage inflammatory protein 1 a (MIP-1 a ), a C–C chemokine with monocyte chemoattractant capability, in excisional wound repair. Both MIP-1 a mRNA and protein were detectable in murine wounds from 12 h through… CONTINUE READING