MIN6 beta-cell-beta-cell interactions influence insulin secretory responses to nutrients and non-nutrients.

@article{Luther2006MIN6BI,
  title={MIN6 beta-cell-beta-cell interactions influence insulin secretory responses to nutrients and non-nutrients.},
  author={Melanie J Luther and Astrid C. Hauge-Evans and Kleber L.A. Souza and Anne Joerns and Sigurd Lenzen and Shanta J Persaud and Peter Martin Jones},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={343 1},
  pages={99-104}
}
Insulin-secreting MIN6 cells show greatly enhanced secretory responsiveness to nutrients when grown as islet-like structures (pseudoislets). Since beta-cells use different mechanisms to respond to nutrient and non-nutrient stimuli, we have now investigated the role of homotypic beta-cell interactions in secretory responses to pharmacological or receptor-operated non-nutrient stimuli in MIN6 pseudoislets. In addition to an enhanced secretory responsiveness to glucose, insulin secretion from MIN6… CONTINUE READING
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