MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling.

@article{Bershteyn2010MIMAC,
  title={MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling.},
  author={Marina Bershteyn and Scott X Atwood and Wei-Meng Woo and Mischa Li and Anthony E Oro},
  journal={Developmental cell},
  year={2010},
  volume={19 2},
  pages={270-83}
}
The primary cilium is critical for transducing Sonic hedgehog (Shh) signaling, but the mechanisms of its transient assembly are poorly understood. Previously we showed that the actin regulatory protein Missing-in-Metastasis (MIM) regulates Shh signaling, but the nature of MIM's role was unknown. Here we show that MIM is required at the basal body of mesenchymal cells for cilia maintenance, Shh responsiveness, and de novo hair follicle formation. MIM knockdown results in increased Src kinase… CONTINUE READING

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