MIF produced by bone marrow-derived macrophages contributes to teratoma progression after embryonic stem cell transplantation.

@article{Wang2012MIFPB,
  title={MIF produced by bone marrow-derived macrophages contributes to teratoma progression after embryonic stem cell transplantation.},
  author={X. Wang and Tianxiang Chen and L. Leng and Jianqing Fan and K. Cao and Zhaoxia Duan and X. Zhang and C. Shao and M. Wu and I. Tadmori and Tian-yi Li and L. Liang and D. Sun and S. Zheng and A. Meinhardt and W. Young and R. Bucala and Yi Ren},
  journal={Cancer research},
  year={2012},
  volume={72 11},
  pages={
          2867-78
        }
}
Although stem cell therapy holds promise as a potential treatment in a number of diseases, the tumorigenicity of embryonic stem cells (ESC) and induced pluripotent stem cells remains a major obstacle. In vitro predifferentiation of ESCs can help prevent the risk of teratoma formation, yet proliferating neural progenitors can generate tumors, especially in the presence of immunosuppressive therapy. In this study, we investigated the effects of the microenvironment on stem cell growth and… Expand
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References

SHOWING 1-10 OF 59 REFERENCES
The anti-apoptotic gene survivin contributes to teratoma formation by human embryonic stem cells
  • 147
The tumorigenicity of diploid and aneuploid human pluripotent stem cells
  • 131
  • Highly Influential
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth
  • 382
  • PDF
The tumorigenicity of human embryonic stem cells.
  • 398
Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response
  • J. Nussbaum, Elina Minami, +7 authors C. Murry
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2007
  • 599
Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
  • 1,878
Human Embryonic Stem Cells Suppress T Cell Responses via Arginase I-Dependent Mechanism
  • 48
  • PDF
The tumorigenicity of human embryonic and induced pluripotent stem cells
  • 683
  • PDF
Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro.
  • J. Fair, B. Cairns, +10 authors J. Frelinger
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
  • 42
  • PDF
...
1
2
3
4
5
...