MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

@article{Bernhagen2007MIFIA,
  title={MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment},
  author={J. Bernhagen and Regina M. Krohn and H. Lue and Julia L. Gregory and A. Zernecke and R. R. Koenen and M. Dewor and Ivan T. Georgiev and A. Schober and L. Leng and T. Kooistra and G. Fingerle-Rowson and P. Ghezzi and R. Kleemann and S. McColl and R. Bucala and M. Hickey and C. Weber},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={587-596}
}
The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in inflammatory diseases and atherogenesis. We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF. MIF triggered Gαi- and integrin-dependent arrest and chemotaxis of monocytes and T cells, rapid integrin activation and calcium influx through CXCR2 or CXCR4. MIF competed with cognate ligands for CXCR4 and CXCR2 binding, and directly bound to CXCR2. CXCR2 and CD74 formed a receptor… Expand
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