MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models

@article{FingerleRowson2007MIFCT,
  title={MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models},
  author={Guenter Fingerle-Rowson and Oleksi Petrenko},
  journal={Cell Division},
  year={2007},
  volume={2},
  pages={22 - 22}
}
Macrophage migration inhibitory factor (MIF) is a ubiquitously expressed pro-inflammatory mediator that has also been implicated in the process of oncogenic transformation and tumor progression. We used a genetic approach to show that deletion of the MIF gene in mice has several major consequences for the proliferative and transforming properties of cells. MIF-deficient cells exhibit increased resistance to oncogenic transformation. The transformation defects associated with MIF deficiency can… CONTINUE READING