MICs of Mutacin B-Ny266, Nisin A, Vancomycin, and Oxacillin against Bacterial Pathogens

@article{MotaMeira2000MICsOM,
  title={MICs of Mutacin B-Ny266, Nisin A, Vancomycin, and Oxacillin against Bacterial Pathogens},
  author={M. Mota-Meira and G. LaPointe and C. Lacroix and M. Lavoie},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2000},
  volume={44},
  pages={24 - 29}
}
ABSTRACT Peptide antibiotics, particularly lantibiotics, are good candidates for replacing antibiotics to which bacteria have become resistant. In order to compare two such lantibiotics with two antibiotics, the MICs of nisin A, mutacin B-Ny266, vancomycin, and oxacillin against various bacterial pathogens were determined. The results indicate that nisin A and mutacin B-Ny266 are as active as vancomycin and oxacillin against most of the strains tested. Furthermore, mutacin B-Ny266 remains… Expand

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References

SHOWING 1-10 OF 45 REFERENCES
Antibacterial efficacy of nisin against multidrug-resistant Gram-positive pathogens.
TLDR
Treatment of growing cultures with nisin caused extensive loss of viable titre accompanied by various degrees of loss in the optical density of the cultures, which was most extensive in pneumococci and least extensive in enterococci, and extensive variation in rates of nisin-induced autolysis was observed in each bacterial species. Expand
Properties of mutacin b, an antibacterial substance produced by Streptococcus mutans strain BHT.
: An antibacterial substance produced by strain BHT of Streptococcus mutans (mutacin b) was found to be a small molecule (MW 3,500-6,000) with remarkable resistance to temperature, alkali and variousExpand
Properties of mutacin b, an antibacterial substance produced by Streptococcus mutans strain BHT.
TLDR
An antibacterial substance produced by strain BHT of Streptococcus mutans (mutacin b) was found to be a small molecule with remarkable resistance to temperature, alkali and various solvents and it is sensitive to several proteolytic enzymes. Expand
Preliminary characterization of four bacteriocins from Streptococcus mutans.
The various properties of the inhibitory substances produced by Streptococcus mutans strains C67-1, Ny257-S, Ny266, and T8, and the fact that inhibitory zones produced could not be associated withExpand
Genetic and Biochemical Analysis of Mutacin 1140, a Lantibiotic from Streptococcus mutans
TLDR
A number of similarities are observed of mutacin 1140 to epidermin and an S. mutans lantibiotic, B-Ny266, but it appears to have significant differences in the positions of its thioether bridges. Expand
Isolation and biochemical characterization of a novel lantibiotic mutacin from Streptococcus mutans
TLDR
It is reported for the first time the purification and partial biochemical characterization of a lanthionine-containing mutacin peptide from S. mutants T8, a member of the oral biota, and the amino acid composition indicates the presence of lanthions and likely beta-methyllanthionine in a total of about 25 amino acids. Expand
Transferable beta-lactamase. A new mechanism for in vitro penicillin resistance in Streptococcus faecalis.
TLDR
Penicillin resistance and beta lactamase activity were transferred by conjugation at a high frequency to an enterococcal laboratory recipient strain together with two plasmids of molecular size 34 X 10(6) and 56 X10(6), thus demonstrating the emergence of plasmid-mediated penicillin Resistance in the genus Streptococcus. Expand
Characterization of Multiresistant Strains of Neisseria gonorrhoeae Isolated in Nicaragua
TLDR
This is the first study that characterizes 18 strains of N. gonorrhoeae isolated in Nicaragua, for their antibiotic susceptibility, and finds that they possess high levels of resistance to multiple families of drugs. Expand
Production and properties of bacteriocins (mutacins) from Streptococcus mutans.
TLDR
Results suggest that mutacins contain at least 2 kinds of inhibitory substances ranging from low molecular weight materials to higher molecular weight, protein-lipid complexes. Expand
Nisin Resistance in Clostridium botulinum Spores and Vegetative Cells
The frequencies at which vegetative cells and spores of Clostridium botulinum strains 56A, 62A, 17409A, 25763A, 213B, B-aphis, and 169B formed colonies on agar media containing 0, 10(sup2), 10(sup3),Expand
...
1
2
3
4
5
...