MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter.

@article{Kamer2014MICU1AM,
  title={MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter.},
  author={Kimberli J Kamer and Vamsi K. Mootha},
  journal={EMBO reports},
  year={2014},
  volume={15 3},
  pages={
          299-307
        }
}
The mitochondrial uniporter is a selective Ca(2+) channel regulated by MICU1, an EF hand-containing protein in the organelle's intermembrane space. MICU1 physically associates with and is co-expressed with a paralog, MICU2. To clarify the function of MICU1 and its relationship to MICU2, we used gene knockout (KO) technology. We report that HEK-293T cells lacking MICU1 or MICU2 lose a normal threshold for Ca(2+) intake, extending the known gating function of MICU1 to MICU2. Expression of MICU1… CONTINUE READING
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