MICA polymorphism in a sample of the São Paulo population, Brazil.

@article{Marin2004MICAPI,
  title={MICA polymorphism in a sample of the S{\~a}o Paulo population, Brazil.},
  author={Maria L{\'u}cia Carnevale Marin and Cynthia Savioli and Joyce Hisae Yamamoto and Jorge Agle Kalil and Anna Carla Goldberg},
  journal={European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics},
  year={2004},
  volume={31 2},
  pages={63-71}
}
The major histocompatibility complex (MHC) class I chain-related A (MICA) gene, located near HLA-B, codes for protein products with structural similarities to those of classical MHC class I genes, but which neither bind beta(2)-microglobulin nor present peptide. Expressed predominantly on gastrointestinal and tumour epithelial cells, they are stress-induced and interact with C-type lectin like receptor (NKG2D) on gammadelta, alphabeta CD8+ T cells and natural killer (NK) cells. MICA is highly… CONTINUE READING