MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia.

@article{Viny2010MICAPI,
  title={MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia.},
  author={Aaron D Viny and Michael J. Clemente and Monika Jasek and Medhat Askar and Hemant Ishwaran and Amy S. Nowacki and Aiwen Zhang and Jaroslaw Maciejewski},
  journal={Haematologica},
  year={2010},
  volume={95 10},
  pages={
          1713-21
        }
}
BACKGROUND Large granular lymphocyte leukemia is a semi-autonomous clonal proliferation of cytotoxic T cells accompanied by immune cytopenias and various autoimmune conditions. Due to the rarity of this disease and its association with autoimmune diseases, a theoretical germline or somatic mutation might have significant penetrance, thus enabling detection, even from samples of suboptimal size, through genome-wide association studies. DESIGN AND METHODS To investigate a non-mendelian genetic… CONTINUE READING

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