MIB1/Ki-67 labelling index can classify grade 2 breast cancer into two clinically distinct subgroups

@article{Aleskandarany2010MIB1Ki67LI,
  title={MIB1/Ki-67 labelling index can classify grade 2 breast cancer into two clinically distinct subgroups},
  author={Mohammed A. Aleskandarany and Emad A Rakha and R. Douglas Macmillan and Des Powe and Ian O. Ellis and Andrew R. Green},
  journal={Breast Cancer Research and Treatment},
  year={2010},
  volume={127},
  pages={591-599}
}
Histological grade is recognized as one of the strongest prognostic factors in operable breast cancer (BC). Although grade 1 and grade 3 tumours are biologically and clinically distinct, grade 2 tumours bear considerable difficulty in outcome prediction and planning therapies. Several attempts such as genomic grade index have been performed to subclassify grade 2 into two subgroups with clinical relevance. Here, we present evidence that the routinely evaluable immunohistochemical MIB1/Ki67… CONTINUE READING

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