MHVR-independent cell-cell spread of mouse hepatitis virus infection requires neutral pH fusion.
@article{Nash1995MHVRindependentCS, title={MHVR-independent cell-cell spread of mouse hepatitis virus infection requires neutral pH fusion.}, author={T C Nash and Thomas M. Gallagher and Michael J. Buchmeier}, journal={Advances in experimental medicine and biology}, year={1995}, volume={380}, pages={ 351-7 } }
Receptor-specificity is a key determinant of viral tropism. In this report, however, we have demonstrated that cell-associated spread of MHV can bypass the requirement for binding to primary receptors and thereby spread to cells that are resistant to MHV infection. Anti-receptor antibody CC1, which blocks infection by MHV virions, failed to prevent cell-associated spread of MHV to receptor-negative BHK cells or receptor-positive DBT cells. Cell-associated MHV may be utilizing an alternative…
4 Citations
Role of Endocytosis and Low pH in Murine Hepatitis Virus Strain A59 Cell Entry
- BiologyJournal of Virology
- 2007
The results imply that endocytosis plays a major role in MHV-A59 infection and the acidic pH of the endosomal compartment triggers a conformational change of the S protein mediating fusion.
Pathogenesis of Murine Coronavirus Infection
- Biology, Medicine
- 2008
This chapter discusses primarily infections of the central nervous system (CNS) and the liver, which provide animal models for human diseases such as hepatitis and encephalitis, demyelinating diseasessuch as multiple sclerosis, and, most recently, respiratory disease such as severe acute respiratory syndrome (SARS).
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
- Biology, MedicineScience
- 2020
Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, preexisting humoral immunity was detected and antibodies targeting the S2 subunit were particularly prevalent in children and adolescents.
Visualisierung und Charakterisierung der S-Protein vermittelten Fusion von Coronaviren
- Biology
- 2008
The results imply that endocytosis plays a major role in MHV-A59 infection and that the acidic pH of the endosomal compartment triggers a conformational change of the S-protein mediating fusion.
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