MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation

Abstract

N-linked glycans are thought to protect class II major histocompatibility complex (MHC) molecules (MHCII) from proteolytic cleavage and assist in arranging proteins within the immune synapse, but were not thought to directly participate in antigen presentation. Here, we report that antigen-presenting cells (APCs) lacking native complex N-glycans showed… (More)
DOI: 10.1084/jem.20100508

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