MHC2TA promoter polymorphism (-168*G/A, rs3087456) is not associated with susceptibility to rheumatoid arthritis in British Caucasian rheumatoid arthritis patients.

@article{Harrison2007MHC2TAPP,
  title={MHC2TA promoter polymorphism (-168*G/A, rs3087456) is not associated with susceptibility to rheumatoid arthritis in British Caucasian rheumatoid arthritis patients.},
  author={Pille Harrison and Jennifer J. Pointon and Christopher D. Farrar and Anantham Harin and Bryan Paul Wordsworth},
  journal={Rheumatology},
  year={2007},
  volume={46 3},
  pages={
          409-11
        }
}
OBJECTIVE To investigate the association of a single-nucleotide polymorphism (SNP) in the promoter region of MHC2TA gene (-168*G/A, rs3087456), which has previously been described in a Swedish rheumatoid arthritis (RA) cohort, in British Caucasian RA patients. METHODS We genotyped 733 RA patients and 613 healthy controls for MHC2TA -168*G/A SNP by amplification-refractory mutation system (ARMS). Data were analysed using SPSS version 13.0 software and the chi-square test was applied where… CONTINUE READING

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