MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction

@article{Swanberg2005MHC2TAIA,
  title={MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction},
  author={Maria Swanberg and Olle Lidman and Leonid Padyukov and Per Eriksson and Eva {\AA}kesson and Maja Jagodic and Anna Lobell and Mohsen Khademi and Ola B{\"o}rjesson and Cecilia M. Lindgren and Pia Lundman and Anthony J. Brookes and Juha Kere and Holger Luthman and Lars Alfredsson and Jan Hillert and Lars Klareskog and Anders Hamsten and Fredrik Piehl and Tomas Olsson},
  journal={Nature Genetics},
  year={2005},
  volume={37},
  pages={486-494}
}
Antigen presentation to T cells by MHC molecules is essential for adaptive immune responses. To determine the exact position of a gene affecting expression of MHC molecules, we finely mapped a previously defined rat quantitative trait locus regulating MHC class II on microglia in an advanced intercross line. We identified a small interval including the gene MHC class II transactivator (Mhc2ta) and, using a map over six inbred strains combined with gene sequencing and expression analysis, two… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 160 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

The EIRA study group. A gene-environment interaction between smoking and shared epitope genes in HLADRB1 provides a high risk of seropositive rheumatoid arthritis

  • L.C.S. Padyukov, P. Stolt, L. Alfredsson, L. Klareskog
  • Arthritis Rheum
  • 2004

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

  • H Ueda
  • Nature 423,
  • 2003

Similar Papers

Loading similar papers…