MHC polymorphism pre-dating speciation

  title={MHC polymorphism pre-dating speciation},
  author={Felipe Figueroa and Eberhardt G{\'u}nther and J. Klein},
Two features distinguish the polymorphism of the major histocom-patibility complex (MHC) loci from that of other loci: its high diversity and the large genetic distance between MHC alleles1,2. More than 100 alleles exist in natural populations in the mouse at each of the functional class I and class II alleles, all alleles occurring at frequencies that cannot be explained by recurrent mutations2,3. Some of the alleles differ by approximately 70 nucleo-tides in the coding region alone and some… CONTINUE READING

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