MHC polymorphism and parasites.

@article{Klein1994MHCPA,
  title={MHC polymorphism and parasites.},
  author={Jan Klein and Colm O'huigin},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={1994},
  volume={346 1317},
  pages={
          351-7; discussion 357-8
        }
}
The major histocompatibility complex (MHC) polymorphism is marked by the existence of allelic lineages that are extremely old, having been passed from one species to another in an evolutionary line of descent. Each species has several of these lineages and many of their more recent derivatives, the actual alleles. The lineages are separated by large genetic distances and are characterized by the presence of short sequence motifs which, at the protein level, have remained virtually unaltered for… CONTINUE READING
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