MHC-like molecules in some nonmammalian vertebrates can be detected by some cross-reactive xenoantisera.

@article{Kaufman1990MHClikeMI,
  title={MHC-like molecules in some nonmammalian vertebrates can be detected by some cross-reactive xenoantisera.},
  author={Jim Kaufman and Karsten Skjoedt and Jan Salomonsen and Morten Simonsen and Louis du Pasquier and Ruth F. Parisot and Patricia Riegert},
  journal={Journal of immunology},
  year={1990},
  volume={144 6},
  pages={2258-72}
}
Rabbit antisera raised to human and chicken MHC molecules were used to immunoprecipitate cross-reactive molecules from biosynthetically and cell surface-labeled spleen and/or blood cells of representative vertebrate species. Five major points emerged: 1) There were many nonspecific cross-reactions using these techniques, so various criteria were developed to distinguish these from true MHC-like molecules. 2) Only very small subpopulations of immunogen-specific antibodies cross-reacted with MHC… CONTINUE READING