MHC gene copy number variation in Tasmanian devils: implications for the spread of a contagious cancer.

@article{Siddle2010MHCGC,
  title={MHC gene copy number variation in Tasmanian devils: implications for the spread of a contagious cancer.},
  author={Hannah V. T. Siddle and Jolanta Marzec and Yuanyuan Cheng and Menna E. Jones and Katherine Belov},
  journal={Proceedings. Biological sciences},
  year={2010},
  volume={277 1690},
  pages={2001-6}
}
Tasmanian devils face extinction owing to the emergence of a contagious cancer. Devil facial tumour disease (DFTD) is a clonal cancer spread owing to a lack of major histocompatibility complex (MHC) barriers in Tasmanian devil populations. We present a comprehensive screen of MHC diversity in devils and identify 25 MHC types and 53 novel sequences, but conclude that overall levels of MHC diversity at the sequence level are low. The majority of MHC Class I variation can be explained by allelic… CONTINUE READING
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