MHC-correlated mate choice in humans: A review

@article{Havlek2009MHCcorrelatedMC,
  title={MHC-correlated mate choice in humans: A review},
  author={Jan Havl{\'i}{\vc}ek and Susan C. Roberts},
  journal={Psychoneuroendocrinology},
  year={2009},
  volume={34},
  pages={497-512}
}
Extremely high variability in genes of the major histocompatibility complex (MHC) in vertebrates is assumed to be a consequence of frequency-dependent parasite-driven selection and mate preferences based on promotion of offspring heterozygosity at MHC, or potentially, genome-wide inbreeding avoidance. [...] Key Method These are based on three broadly different aspects: (1) odor preferences, (2) facial preferences and (3) actual mate choice surveys. As in animal studies, most odor-based studies demonstrate…Expand
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Findings provide further support for a special role of the MHC in human sexual selection and suggest that male and female mate preferences may work together to potentially enhance both male andFemale reproductive success by increasing genetic diversity in offspring. Expand
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TLDR
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The Major Histocompatibility Complex in Song Sparrows: Immunity, Signals, and Mate Choice
TLDR
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There appears to be a general preference expressed for M HC-dissimilar mates, and such MHC-disassortative mating may be involved in maintaining MHC and/or genome-wide diversity in natural populations. Expand
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The evidence for MHC-dependent mating preferences from recent studies is reviewed, including studies on the underlying olfactory mechanisms and evolutionary functions, and other ways that MHC genes might influence sexual selection are discussed. Expand
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It is proposed that MHC‐dependent mating preferences enable hosts to provide a “moving target” against rapidly evolving parasites that escape immune recognition (the Red Queen hypothesis) and may also function to avoid inbreeding. Expand
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Females gain direct or indirect fitness benefits by choosing between males with traits indicating bgood genes,Q but we usually know very little about the nature of these genes. However, it has beenExpand
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