MHC class II-transfected tumor cells directly present antigen to tumor-specific CD4+ T lymphocytes.

@article{Armstrong1998MHCCI,
  title={MHC class II-transfected tumor cells directly present antigen to tumor-specific CD4+ T lymphocytes.},
  author={Todd D. Armstrong and Virginia K. Clements and Suzanne Ostrand-Rosenberg},
  journal={Journal of immunology},
  year={1998},
  volume={160 2},
  pages={661-6}
}
We have developed and shown to be efficacious an immunotherapeutic strategy to enhance the generation of tumor-specific CD4+ T helper lymphocytes. The approach uses autologous tumor cells genetically modified to express syngeneic MHC class II genes as cell-based immunogens and is based on the hypothesis that tumor cells directly present tumor Ags to CD4+ T cells. Since the conventional pathway for CD4+ T cell activation is indirect via professional APC, induction of immunity following… CONTINUE READING

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