MHC class II transactivator negatively regulates RANKL-mediated osteoclast differentiation by downregulating NFATc1 and OSCAR.

@article{Kim2010MHCCI,
  title={MHC class II transactivator negatively regulates RANKL-mediated osteoclast differentiation by downregulating NFATc1 and OSCAR.},
  author={Jung Ha Kim and Kabsun Kim and Bang Ung Youn and Hye Mi Jin and Nacksung Kim},
  journal={Cellular signalling},
  year={2010},
  volume={22 9},
  pages={1341-9}
}
Nuclear factor of activated T cells (NFAT) c1 plays a key role in receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclast differentiation and function via induction of osteoclast-specific target genes including osteoclast-associated receptor (OSCAR), cathepsin K, and tartrate-resistant acid phosphatase. To elucidate which downstream target genes are regulated by NFATc1 during osteoclastogenesis, we used microarray analyses to examine gene expression profiles in the context… CONTINUE READING

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