MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers

  title={MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers},
  author={Christian Steidl and Sohrab P. Shah and Bruce W. Woolcock and Lixin Rui and Masahiro Kawahara and Pedro Farinha and Nathalie A. Johnson and Yongjun Zhao and Adele Telenius and Susana Ben Neriah and Andrew W McPherson and Barbara Meissner and Ujunwa C. Okoye and Arjan Diepstra and A. V. van den Berg and Mark Denne Sun and Gillian P Leung and Steven J. Jones and Joseph M. Connors and David G. Huntsman and Kerry J. Savage and Lisa M Rimsza and Douglas E. Horsman and Louis M. Staudt and Ulrich Steidl and Marco A. Marra and Randy D. Gascoyne},
Chromosomal translocations are critically involved in the molecular pathogenesis of B-cell lymphomas, and highly recurrent and specific rearrangements have defined distinct molecular subtypes linked to unique clinicopathological features. In contrast, several well-characterized lymphoma entities still lack disease-defining translocation events. To identify novel fusion transcripts resulting from translocations, we investigated two Hodgkin lymphoma cell lines by whole-transcriptome paired-end… CONTINUE READING
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