MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.

@article{Gassart2008MHCCI,
  title={MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.},
  author={Aude de Gassart and Voahirana Camosseto and Jacques Thibodeau and Maurizio Ceppi and Nadia Catalan and Philippe Pierre and Evelina Gatti},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 9},
  pages={3491-6}
}
In response to Toll-like receptor ligands, dendritic cells (DCs) dramatically enhance their antigen presentation capacity by stabilizing at the cell-surface MHC II molecules. We demonstrate here that, in human monocyte-derived DCs, the RING-CH ubiquitin E3 ligase, membrane-associated RING-CH I (MARCH I), promotes the ubiquitination of the HLA-DR beta-chain. Thus, in nonactivated DCs, MARCH I induces the surface internalization of mature HLA-DR complexes, therefore reducing their stability and… CONTINUE READING
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