MHC class II-restricted tumor antigens recognized by CD4+ T cells: new strategies for cancer vaccine design.

@article{Zeng2001MHCCI,
  title={MHC class II-restricted tumor antigens recognized by CD4+ T cells: new strategies for cancer vaccine design.},
  author={Gang Zeng},
  journal={Journal of immunotherapy},
  year={2001},
  volume={24 3},
  pages={195-204}
}
  • Gang Zeng
  • Published 2001 in Journal of immunotherapy
The adoptive transfer of tumor-infiltrating lymphocytes (TIL) can mediate tumor regression in patients with melanoma. This finding has led to the identification and characterization of tumor-associated antigens recognized by CD8+ TIL. Several clinical trials based on the genes recognized by these CD8+ T cells have been attempted, but with only limited success. Meanwhile, increasing evidence has demonstrated that CD4+ T cells play important roles in generating and maintaining antitumor immune… CONTINUE READING
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