MHC class II-positive perivascular microglial cells mediate resistance to Cryptococcus neoformans brain infection.

@article{Aguirre2002MHCCI,
  title={MHC class II-positive perivascular microglial cells mediate resistance to Cryptococcus neoformans brain infection.},
  author={Karen Aguirre and Shannon Miller},
  journal={Glia},
  year={2002},
  volume={39 2},
  pages={184-8}
}
Acquired resistance to the CNS pathogen Cryptococcus neoformans is mediated by CD4(+) T lymphocytes primed by exposure to antigen in the context of major histocompatibility class II (MHC II) molecules. In mouse brain, parenchymal and perivascular microglial cells may express interferon-gamma (IFN-gamma)-inducible MHC class II marker and thus interact with CD4(+) T cells. Primed effector T cells are retained in the infected CNS if antigen is encountered in proper MHC context and may deliver… CONTINUE READING
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