MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation.

@article{Gregers2003MHCCI,
  title={MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation.},
  author={Tone F. Gregers and Burkhard Fleckenstein and Frode Vartdal and Peter Roepstorff and Oddmund Bakke and Inger Sandlie},
  journal={International immunology},
  year={2003},
  volume={15 11},
  pages={1291-9}
}
CD4(+) T cells recognize peptides presented on the cell surface of antigen presenting cells in the MHC class II context. The biosynthesis and transport of MHC class II molecules depend on the type II transmembrane invariant chain (Ii) and are tightly regulated processes. Ii is known to bind to the MHC class II peptide-binding groove via its class II-associated Ii peptide (CLIP) region early in the biosynthetic pathway to prevent premature peptide binding. In this study we have genetically… CONTINUE READING