MHC class II invariant chains in antigen processing and presentation.

@article{Koch1989MHCCI,
  title={MHC class II invariant chains in antigen processing and presentation.},
  author={Norbert Koch and Joachim Lipp and Ulrich Pessara and Karl Schenck and C J Wraight and Bernhard Dobberstein},
  journal={Trends in biochemical sciences},
  year={1989},
  volume={14 9},
  pages={
          383-6
        }
}
Most protein antigens cannot elicit a T-cell response unless they are processed to peptides, which are then presented to T lymphocytes by surface MHC class II molecules. Recent evidence supports an essential role of the invariant chain associated with class II MHC polypeptides in antigen processing.