MHC class II epitope predictive algorithms.

  title={MHC class II epitope predictive algorithms.},
  author={Morten Nielsen and Ole Lund and S\oren Buus and Claus Lundegaard},
  volume={130 3},
SUMMARY Major histocompatibility complex class II (MHC-II) molecules sample peptides from the extracellular space, allowing the immune system to detect the presence of foreign microbes from this compartment. To be able to predict the immune response to given pathogens, a number of methods have been developed to predict peptide-MHC binding. However, few methods other than the pioneering TEPITOPE/ProPred method have been developed for MHC-II. Despite recent progress in method development, the… CONTINUE READING