MHC class I expression on tumor targets inhibits natural killer cell-mediated cytotoxicity without interfering with target recognition.

Abstract

NK cell-mediated killing is inversely proportional to the amount of MHC class I expression on certain tumor targets. Two hypotheses have been proposed to explain why class I-bearing targets are more resistant to NK cell-mediated lysis: 1) the presence of class I prevents NK cell recognition of a triggering molecule on the target cell surface, or 2) class I… (More)

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