MHC class I down-regulation: tumour escape from immune surveillance? (review).

@article{Bubenk2004MHCCI,
  title={MHC class I down-regulation: tumour escape from immune surveillance? (review).},
  author={Jan Buben{\'i}k},
  journal={International journal of oncology},
  year={2004},
  volume={25 2},
  pages={487-91}
}
  • Jan Bubeník
  • Published 2004 in International journal of oncology
Malignant conversion and subsequent in vivo selection can give rise to the cell populations that show stable expression of an immune escape phenotype, MHC class I deficient neoplasms. Deficiencies associated with the MHC class I down-regulation are either irreversible, such as beta2 microglobulin and class I heavy chain gene disabling mutations, or reversible. The reversible MHC class I deficiencies involve all levels of the MHC class I-restricted antigen presentation machinery. They can be… CONTINUE READING
70 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 70 extracted citations

Similar Papers

Loading similar papers…