MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue

@inproceedings{Ghadially2017MHCCI,
  title={MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue},
  author={Hormas Ghadially and Lee C Brown and Chris Lloyd and Leeanne Lewis and Arthur Lewis and Janette Dillon and Richard C. A. Sainson and Jelena Jovanovi{\'c} and Natalie J. Tigue and David Bannister and Lisa Bamber and Viia Valge-Archer and Robert W. Wilkinson},
  booktitle={British Journal of Cancer},
  year={2017}
}
Background:Major histocompatibility complex (MHC) class I chain-related protein A (MICA) and MHC class I chain-related protein B (MICB) are polymorphic proteins that are induced upon stress, damage or transformation of cells which act as a ‘kill me’ signal through the natural-killer group 2, member D receptor expressed on cytotoxic lymphocytes. MICA/B are not thought to be constitutively expressed by healthy normal cells but expression has been reported for most tumour types. However, it is not… CONTINUE READING
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