MHC class I chain-related gene a alleles distinguish malnutrition-modulated diabetes, insulin-dependent diabetes, and non-insulin- dependent diabetes mellitus patients from eastern India.

@article{Sanjeevi2002MHCCI,
  title={MHC class I chain-related gene a alleles distinguish malnutrition-modulated diabetes, insulin-dependent diabetes, and non-insulin- dependent diabetes mellitus patients from eastern India.},
  author={Carani Balaraman Sanjeevi and Alok Kanungo and Laima Berzina and A Shtauvere-Brameus and Mehran Ghaderi and Kailash Chandra Samal},
  journal={Annals of the New York Academy of Sciences},
  year={2002},
  volume={958},
  pages={341-4}
}
Insulin-dependent diabetes mellitus (IDDM) is a polygenic disorder with an autoimmune basis for disease development. In addition to HLA, a second susceptibility locus for IDDM has been identified to lie in the major histocompatibility class III region. MIC-A is located in the MHC class III region and is expressed by monocytes, keratinocytes, and endothelial cells. Sequence determination of the MIC-A gene identifies trinucleotide repeat (GCT) microsatellite polymorphism in exon 5. Five alleles… CONTINUE READING