MHC class I antigens, immune surveillance, and tumor immune escape.

@article{GarciaLora2003MHCCI,
  title={MHC class I antigens, immune surveillance, and tumor immune escape.},
  author={Angel Miguel Garcia-Lora and Ignacio Algarra and Federico Garrido},
  journal={Journal of cellular physiology},
  year={2003},
  volume={195 3},
  pages={346-55}
}
Oncogenic transformation in human and experimental animals is not necessarily followed by the appearance of a tumor mass. The immune system of the host can recognize tumor antigens by the presentation of small antigenic peptides to the receptor of cytotoxic T-lymphocytes (CTLs) and reject the nascent tumor. However, cancer cells can sometimes escape these specific T-cell immune responses in the course of somatic (genetic and phenotypic) clonal evolution. Among the tumor immune escape mechanisms… CONTINUE READING