MHC class I antigen processing regulated by cytosolic proteolysis-short cuts that alter peptide generation.

@article{Kessler2002MHCCI,
  title={MHC class I antigen processing regulated by cytosolic proteolysis-short cuts that alter peptide generation.},
  author={Benedikt M. Kessler and Rickard Glas and Hidde L. Ploegh},
  journal={Molecular immunology},
  year={2002},
  volume={39 3-4},
  pages={171-9}
}
Cytotoxic T lymphocyte (CTL)-mediated immune responses rely on the efficiency of MHC class I ligand generation and presentation by antigen presenting cells (APCs). Whereas the abnormal expression of MHC molecules and transporters associated with antigen processing (TAPs) are commonly discussed as factors that modulate antigen presentation, much less is known about possible regulatory mechanisms at the level of proteolysis responsible for the generation of antigenic peptides. The ubiquitin… CONTINUE READING
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