MHC class I antigen presentation: learning from viral evasion strategies

@article{Hansen2009MHCCI,
  title={MHC class I antigen presentation: learning from viral evasion strategies},
  author={T. Hansen and M. Bouvier},
  journal={Nature Reviews Immunology},
  year={2009},
  volume={9},
  pages={503-513}
}
  • T. Hansen, M. Bouvier
  • Published 2009
  • Biology, Medicine
  • Nature Reviews Immunology
  • The cell surface display of peptides by MHC class I molecules to lymphocytes provides the host with an important surveillance mechanism to protect against invading pathogens. However, in turn, viruses have evolved elegant strategies to inhibit various stages of the MHC class I antigen presentation pathway and prevent the display of viral peptides. This Review highlights how the elucidation of mechanisms of viral immune evasion is important for advancing our understanding of virus–host… CONTINUE READING

    Figures and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    8 Regulation of MHC Class I by Viruses
    Regulation of MHC Class I by Viruses
    1

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 148 REFERENCES
    Herpes simplex virus turns off the TAP to evade host immunity
    765
    A viral inhibitor of peptide transporters for antigen presentation
    513