MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells

@article{Karlhofer1992MHCCI,
  title={MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells},
  author={Franz M. Karlhofer and Randall K. Ribaudo and Wayne M Yokoyama},
  journal={Nature},
  year={1992},
  volume={358},
  pages={66-70}
}
THE molecular basis of target cell recognition by CD3− natural killer (NK) cells is poorly understood, despite the ability of NK cells to lyse specific tumour cells1,2. In general, target cell major histocompatibility complex (MHC) class I antigen expression correlates with resistance to NK cell-mediated lysis3–9, possibly because NK cell-surface molecules engage MHC class I antigens and consequently deliver inhibitory signals3,4. Natural killer cell allospecificity involves the MHC class I… CONTINUE READING