MHC class I A region diversity and polymorphism in macaque species

@article{Otting2007MHCCI,
  title={MHC class I A region diversity and polymorphism in macaque species},
  author={Nel Otting and Annemiek J. M. de Vos-Rouweler and Corrine M. C. Heijmans and Natasja G. de Groot and Gaby G. M. Doxiadis and Ronald Bontrop},
  journal={Immunogenetics},
  year={2007},
  volume={59},
  pages={367 - 375}
}
The HLA-A locus represents a single copy gene that displays abundant allelic polymorphism in the human population, whereas, in contrast, a nonhuman primate species such as the rhesus macaque (Macaca mulatta) possesses multiple HLA-A-like (Mamu-A) genes, which parade varying degrees of polymorphism. The number and combination of transcribed Mamu-A genes present per chromosome display diversity in a population of Indian animals. At present, it is not clearly understood whether these different A… CONTINUE READING

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