MHC class I–specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice

@inproceedings{Strait2011MHCCI,
  title={MHC class I–specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice},
  author={Richard T. Strait and Wyenona Hicks and Nathaniel Barasa and Ashley M Mahler and Marat V. Khodoun and Joerg Koehl and K. Stringer and David Witte and Nico Van Rooijen and Brian M. Susskind and Fred D. Finkelman},
  booktitle={The Journal of experimental medicine},
  year={2011}
}
Transfusion-related acute lung injury (TRALI), a form of noncardiogenic pulmonary edema that develops during or within 6 h after a blood transfusion, is the most frequent cause of transfusion-associated death in the United States. Because development of TRALI is associated with donor antibodies (Abs) reactive with recipient major histocompatibility complex (MHC), a mouse model has been studied in which TRALI-like disease is caused by injecting mice with anti-MHC class I monoclonal Ab (mAb… CONTINUE READING