MHC class I–deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I–sufficient environment

@inproceedings{Elliott2010MHCCI,
  title={MHC class I–deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I–sufficient environment},
  author={Julie M. Elliott and Joseph A. Wahle and Wayne M Yokoyama},
  booktitle={The Journal of experimental medicine},
  year={2010}
}
In MHC class I-deficient hosts, natural killer (NK) cells are hyporesponsive to cross-linking of activation receptors. Functional competence requires engagement of a self-major histocompatability complex (MHC) class I-specific inhibitory receptor, a process referred to as "licensing." We previously suggested that licensing is developmentally determined in the bone marrow. In this study, we find that unlicensed mature MHC class I-deficient splenic NK cells show gain-of-function and acquire a… CONTINUE READING