MHC I-dependent antigen presentation is inhibited by poliovirus protein 3A.

  title={MHC I-dependent antigen presentation is inhibited by poliovirus protein 3A.},
  author={Stephen B Deitz and Debra A. Dodd and Scott Cooper and Peter Parham and Karla Kirkegaard},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 25},
The effects of poliovirus 3A protein expression and poliovirus infection on the presentation of hepatitis C virus antigens in cultured chimpanzee cells were examined. Expression of poliovirus 3A protein inhibits protein secretion when expressed in isolation and was sufficient to protect chimpanzee cells from lysis by hepatitis C virus-specific cytotoxic T cells in standard (51)Cr-release assays. Poliovirus infection also inhibited antigen presentation, as determined by decreased cytotoxic T… CONTINUE READING

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