MHC Class I–Subversive Gene Functions of Cytomegalovirus and their Regulation by Interferons–an Intricate Balance

Abstract

Multiple glycoproteins of human cytomegalovirus (HCMV) encoded by the genes US2, US3, US6 and US11 interrupt the MHC class I pathway of antigen presentation at distinct checkpoints to avoid recognition of infected cells by cytotoxic CD8+ T lymphocytes. The action of cytokines like interferon (IFN)-γ, IFN-α/β and tumour necrosis factor α (TNF-α) compensate… (More)
DOI: 10.1023/A:1008180229218

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