MH1 domain of SMAD4 binds N-terminal residues of the homeodomain of Hoxc9.


Smad family proteins mediate signaling initiated by bone morphogenetic proteins (BMPs). Upon BMP stimulation, the Smads such as Smad4 can interact directly with Hox proteins and suppress their DNA-binding activity. Although the interaction between the MAD-homology 1 (MH1) domain of Smad4 and Hox was found to regulate the transcription activity of Hox… (More)
DOI: 10.1016/j.bbapap.2008.01.021


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