MGluR5 Mediates the Interaction between Late-LTP, Network Activity, and Learning

@article{Bikbaev2008MGluR5MT,
  title={MGluR5 Mediates the Interaction between Late-LTP, Network Activity, and Learning},
  author={Arthur F Bikbaev and Sergey Neyman and Richard Teke Ngomba and Jeffrey Christopher Conn and Ferdinando Nicoletti and Denise Manahan-Vaughan},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={13453 - 13459}
}
Hippocampal synaptic plasticity and learning are strongly regulated by metabotropic glutamate receptors (mGluRs) and particularly by mGluR5. Here, we investigated the mechanisms underlying mGluR5-modulation of these phenomena. Prolonged pharmacological blockade of mGluR5 with MPEP produced a profound impairment of spatial memory. Effects were associated with 1) a reduction of mGluR1a-expression in the dentate gyrus; 2) impaired dentate gyrus LTP; 3) enhanced CA1-LTP and 4) suppressed theta (5… CONTINUE READING

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