MGUS to myeloma: a mysterious gammopathy of underexplored significance.

@article{Dhodapkar2016MGUSTM,
  title={MGUS to myeloma: a mysterious gammopathy of underexplored significance.},
  author={Madhav V Dhodapkar},
  journal={Blood},
  year={2016},
  volume={128 23},
  pages={2599-2606}
}
All cases of multiple myeloma (MM) are preceded by precursor states termed monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). Genetic analyses of MGUS cells have provided evidence that it is a genetically advanced lesion, wherein tumor cells carry many of the genetic changes found in MM cells. Intraclonal heterogeneity is… CONTINUE READING