MGMT promoter methylation status in anaplastic meningiomas

@article{Brokinkel2010MGMTPM,
  title={MGMT promoter methylation status in anaplastic meningiomas},
  author={Benjamin Brokinkel and Bernhard R. Fischer and Susanne Peetz-Dienhart and Heinrich Ebel and Abolghassem Sepehrnia and Burckhard Rama and Friedrich K. Albert and Walter Stummer and Werner Paulus and Martin Hasselblatt},
  journal={Journal of Neuro-Oncology},
  year={2010},
  volume={100},
  pages={489-490}
}
Anaplastic meningioma [World Health Organization (WHO) grade III] is characterized by aggressive biological behavior and recurrent tumor growth [1]. Radiation therapy is commonly employed after both total and subtotal resection, but effective chemotherapeutic regimens are lacking [2]. Hypermethylation of the O-methylguanine-DNA methyltransferase (MGMT) promoter is an important prognostic marker and also predicts response to therapy with alkylating agents (e.g., temozolomide) in patients with… CONTINUE READING

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